Friday, January 28, 2011

Playing with the living

InternetActu - We are still far from predicting the physicist and mathematician Freeman Dyson (Wikipedia) - which announced in 2007 that "the final step in the domestication of biotechnology will be biotech creating games, designed like computer games for children from kindergarten, but played with real eggs and real seeds instead of images on a screen.

The winner will be the kid who will create the seeds producing the most thorny cactus, or the one whose egg will give birth to the cutest dinosaur "- but slowly approached. If this summer has attracted Foldit (finally) media attention (see our article), other "games of biological research" have emerged since September 2010.

The first of them, achieving the Canadian University of McGill, Phylo, is in line with Folder: This time, it no longer seeks to fold proteins but to compare gene sequences between different species, which would ultimately help to advance research on genetic diseases. In the game, the genes are represented very simply in the form of colored squares moving on a line.

As highlighted in Wired Lisa Grossman, a major difference between Phylo and Folder is only in the first, "science becomes invisible. The game looks more like a puzzle abstract shapes with colored and jazzy music. " In fact, the audience for Phylo would, according to its creators, much wider than that of Folder.

The goal is to create a simple hobby, a casual game as it is known as likely to attract all audiences, science is doing upstream and away from the eyes of players. In keeping with their desire to make a popular game, they plan to offer mobile versions of Facebook and Phylo: goal, supplant Farmville, no less! "PLAYED BY HUMAN NATURE BY REFEREE" Eterna, launched recently at Carnegie Mellon University, goes further in the field of science fun.

The molecule is referred to the NRA this time, the Swiss Army knife of the living cell, responsible (among others) to translate the messages of DNA and protein to help build them. In Eterna, science is much more prevalent than in Phylo; not about to play without at least a notion of concepts being manipulated! ETERNA but also goes further in that folder in the field of "scientific crowdsourcing," the ability to use a large number of Internet users to perform small tasks: for example, is clearly delineated separation between "puzzles" that are used primarily to entrainment and fun, and the Lab, where one expects the player he is working on the synthesis of new molecules.

But mostly, Eterna wants to allow players to see their designs realized in real-Tech News Buzz! That's something designers already Foldit wanted to do: allow the champions of their game to see materialize their own proteins. But that was a long-term Foldit ETERNA happen with every week: the best sequences are realized in the laboratory.

Why this is so difficult to achieve with proteins Foldit is it so easy to accomplish with ETERNA? The reason is simple: the NRA is a single molecule to synthesize. A few hours are enough to get a new macromolecule laboratory. In other words, there are two "scores" in Eterna: firstly, we select the best molecules, those "bend" the best according to the simulation.

And then, winners have their designs synthesized in Tech Buzz News real, and there they will really know if it is viable ... "In Eterna, you win when the synthesized molecule is able to self assemble," says Treuille David, one of the creators of the game "This is the kind that decides the final score: a referee and is very cruel." Beyond the virtual If ETERNA already crossed the border between the virtual and the real, other researchers at Stanford University, are far more: they have developed "games biotic" to interact directly with the living .

The laboratory team Riedel-Kruse has made 8 games, which are divided into three types. The first involves the manipulation of living creatures, in fact paramecia, these single-celled creatures that often studied in college and can grow quite simply with lettuce leaves. The team has created systems to guide these creatures by drawing them through electric fields (or chemicals).

They were able to make a Pacman, a Pong, and even a pinball machine ... The second game takes place at a lower level in the scale of living. It's "PolymerRace" inspired horse racing. The game is based here on the use of PCR (polymerase chain reaction), fundamental operation of modern biotechnology, which involves multiplying the DNA strands to make handling easier.

It turns out that this "chain reaction" is different depending on the DNA molecules involved. It thus becomes possible, the researchers said, to bet on the DNA that will react faster! Coincidence? Not completely, according to Riedel-Kruse, a principal designer of these games: "It takes a little logic and Biomolecular luck.

Certainly, all Tech News Buzz can be a PCR machine in his living room, but remember that there are now versions at very low prices, it could now try small groups of individuals, especially s' ago paris (and therefore money to be made) to the key! The third game is based on the "prisoner's dilemma": it relies on the use by players of yeast colonies.

This single cell is easily recognizable by its distinctive odor. Each, in turn, must participate in a "common pot" where he must share with its partners a bit of his "colony" in a test tube. But there may also place a neutral liquid. The play will recognize "the smell" if his opponent cooperated or "lied" while feeling the mix! This game is perhaps the most interesting and original, for three reasons: first because it is organic, of course, but also because it introduces players to the prisoner's dilemma, one of the fundamental concepts of game theory and complex systems - a key, not only the economy but may also be of sociology or even ecology and biological evolution, and finally, because it involves a faculty human so far has rarely been involved in games: olfaction.

Which suggests that games are not only biotic intake educational or intellectual: they may expand the range of our sensory experience. For Riedel-Kruse and his team, the scope of these games biotic is essentially educational: "You can say that biotechnology will affect our lives increasingly, particularly through biomedical personal choices which we will more often be faced .

All News Tech Buzz should have sufficient knowledge of biomedicine and biotechnology. Biotic games could help it. "But of course, he does not forget other potential markets including crowdsourcing research fostered by the creators of Folder or Eterna. Then, he hopes that the game development biotic accelerate the progress of technology and falling prices for tools.

Finally, he concluded in his paper (. Pdf) for the journal "Lab on a chip," we hope we will play games for fun biotic. Naturally, all these researchers do not work in isolation. Thus, Kuse Riedel joined Rhiju Das, one of the designers of Eterna, and Daniel Schwartz, a professor of science education at Stanford, and founded the Bio-X Game Center "devoted to the development of video games from the living.

Note also qu'EteRNA is a member of "Gameful" founded by Jane McGonigal, who seeks to bring together "game designers who want to change News Tech Buzz." Far from appearing as a series of disconnected academic experiences, the game could become a biological "scene" influential in a game world that increasingly invades our daily experience.

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